And it has a clear, bold ambition: to eliminate the diseased cells driving MPNs to help people with MPNs live longer, healthier and more fulfilling lives.

At the heart of the company is ARTEMIS, a powerful discovery engine that integrates access to extensive human MPN patient samples, single-cell sequencing, advanced bone marrow organoids and other MPN models, and bioinformatics.

This unique combination helps Alethio Therapeutics uncover MPN-specific targets that other approaches miss – and translate them into next-generation therapies.

WHY IT MATTERS

MPNs are caused by mutations in bone marrow stem cells that disrupt normal blood production. Approximately 300,000 people in the US live with MPNs, with 20-25% progressing to advanced disease, such as Myelofibrosis (MF). This causes progressive scarring of the bone marrow, leading to debilitating symptoms and a median survival of 5-7 years. It can also lead to full-blown secondary leukaemia, with an average life expectancy of less than 12 months.

Today’s treatments can slow the disease but don’t cure it – and often come with harsh side effects. There’s an urgent need for therapies that go deeper and eliminate the root cause of disease.

Alethio Therapeutics is meeting that need by developing AT-01, a first-in-class antibody-drug conjugate (ADC) programme designed to bind to the target identified by ARTEMIS and deliver toxic payloads into tumour cells – while sparing healthy ones. It’s an approach that could transform both survival and quality of life for patients living with MPNs.

A FLAGSHIP OF OSE’S MISSION

OSE backed Alethio Therapeutics early, recognising the potential to turn cutting-edge research into high-impact, high-growth innovation.

This is science with both purpose and commercial power – a breakthrough approach addressing a global unmet need, with potential applications across chronic blood cancers and beyond.

Alethio Therapeutics is a flagship example of OSE’s mission in action: finding bold science, backing visionary founders, and building companies that can change the world.